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Quick Details

  • CAS No.: 38304-91-5
  • Other Names: Hair regrowth
  • MF: Hair regrowth
  • EINECS No.: Hair regrowth
  • Place of Origin: Shaanxi, China (Mainland)
  • Type: Auxiliaries and Other Medicinal Chemicals
  • Grade Standard: Cosmetic Grade, Medicine Grade
  • Usage: Animal Pharmaceuticals
  • Brand Name: Hair regrowth
  • Model Number: Hair regrowth
  • Purity: Hair regrowth
  • Appearance: White Crystalline Powder
  • Shelf life: 24 Months
  • Molecular weight: 209.25
  • Melting point: 272-274 °C
  • Flash point: 283.364℃

Packaging & Delivery

Packaging Details 100g/al-foil bag, 1kg/al-foil bag,5KG/al-foil bag, 25kg/drum
Delivery Time Shipped in 2 days after payment

                  Minoxidil 99% Cas 38304-91-5 for Hair Regrowth  

  

Productname Minoxidil 
CAS NO.38304-91-5
Synonym

Loniten,Lonolox,Lonoten,Minona

MFC9H15N5O
MolecularWeight 209.25
CategoryPharmaceutical Raw Materials, Fine Chemicals, Bulk drug
StandardMedical standard
AppearanceWhite Crystalline  powder
Assay
99%
Shelf life2 years
Storage
should be stored in a well-closed container at low temperature, keep away from moisture, heat and light.

                                

 

Introduction:

Minoxidil is an antihypertensive vasodilator medication. It also slows or stops hair loss and promotes hair regrowth in some people. Now off-patent, it is available over-the-counter for the treatment ofandrogenic alopecia.

Minoxidil was the first drug approved by the FDA for the treatment of androgenetic alopecia (hair loss). Before that, minoxidil had been used as vasodilator drug prescribed as oral tablet to treat high blood pressure, with effects that included hair growth and reversal of male baldness. In the 1980s, UpJohn Corporation came out with a topical solution of 2% minoxidil, called Rogaine, for the specific treatment of androgenetic alopecia. Since the 1990s, numerous generic forms of minoxidil have become available to treat hair loss while the oral form is still used to treat high blood pressure.

Minoxidil is a vasodilator medication known for its ability to slow or stop hair loss and promote hair regrowth. It is available over the counter for treatment of androgenic alopecia, among other baldness treatments, but measurable changes disappear within months after discontinuation of treatment. Its effectiveness has largely been demonstrated in younger men (18 to 41 years of age), the younger the better, and in those with balding in the central (vertex) portion of the scalp.
Minoxidil powder is a potassium channel agonist. It contains the chemical structure of nitric oxide), a blood vessel dilator, and may be a nitric oxide agonist. This appears to explain its vasodilatory effects, but may also be linked to minoxidil’s ability to stimulate hair growth and treat hair loss. Since minoxidil is a nitric oxiderelated compound, it was suspected to act via activation of guanylate cyclase, an enzyme involved in vasodilation. 

Medical Use:

Minoxidil, applied topically, is widely used for the treatment of hair loss. It is effective in helping promote hair growth in both males and females with androgenic alopecia.About 40% of men experience hair regrowth after 3–6 months.Minoxidil must be used indefinitely for continued support of existing hair follicles and the maintenance of any experienced hair regrowth.It is the only topical product that is FDA approved for androgenic hair loss.Treatments usually include a 5% concentration solution that is designed for men, and a 2% concentration solution for women.

Mechanism of Action: 

The mechanism by which minoxidil promotes hair growth is not fully understood. Minoxidil is a potassium channel opener, causing hyperpolarization of cell membranes. Hypothetically, by widening blood vessels and opening potassium channels, it allows more oxygen, blood, and nutrients to the follicle. This may cause follicles in the telogen phase to shed, which are then replaced by thicker hairs in a new anagen phase. Minoxidil is a pro-drug activated by sulfation via the sulfotransferase (SULT1A1). Several studies demonstrated that the activity of sulfotransferase in hair follicles predict minoxidil response in the treatment of hair loss.

Minoxidil is less effective when there is a large area of hair loss. In addition, its effectiveness has largely been demonstrated in younger men who have experienced hair loss for less than 5 years. Minoxidil use is indicated for central (vertex) hair loss only.Minoxidil is also a vasodilator.[20] Two clinical studies are being conducted in the US for a medical device that may allow patients to determine if they are likely to fail minoxidil therapy.

Application:

Minoxidil needs to be applied twice daily, and may be used indefinitely for continued support of existing hair follicles and the maintenance of any experienced hair regrowth. To achieve maximum effect, the solution should be in contact with the scalp for at least 4 hours before allowing hair to get wet.Minoxidil stimulates hair follicles and growth, but does not reduce dihydrotestosterone (DHT) or the enzyme responsible for its accumulation around the hair follicle, 5-alpha reductase, which is the primary mediator of male pattern baldness in genetically susceptible individuals.Therefore, when treatment is stopped, the DHT has its expected effect of shrinking and ultimately destroying the genetically predisposed hair follicles. There are multiple types of minoxidil applications: dropper, foam and spray.

Side Effects:

Minoxidil is generally well tolerated, but common side effects include burning or irritation of the eye, itching, redness or irritation at the treated area, as well as unwanted hair growth elsewhere on the body. 

 Certificate of Analysis

Items

Standard USP37

Results

Character

White or almost white crystalline powder

White crystalline powder

Identification:

Positive

Positive

Residue on ignition

≤0.5%

0.05%

Heavy metals

NMT 20ppm

4ppm

Sulphated ash

NMT 0.1%

0.04%

Loss on drying

NMT 0.5%

0.13%

Total impurities

NMT 1.5%

Conforms

Residual solvents

Methanol NMT 3000ppm

Conforms

Ethanol NMT 5000ppm

Conforms

Ethyl acetate NMT 5000ppm

Conforms

Assay(HPLC)

97%-103%

99.52%

Payment Terms:

Western Union

(Suitable for under 1000USD)

Bank Transfer

(Suitable for all amount)

Reasonable bank charges

Arrive time: immediately

Easy to handle

Reasonable bank charges

Arrive time:2-3 work days

Easy to handle 

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About Transportation:

 

 

                               Minoxidil 99% Cas 38304-91-5 for Hair Regrowth 

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