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Quick Details

  • CAS No.: 846589-98-8
  • Other Names: Lorcaserin hcl
  • Place of Origin: Shaanxi, China (Mainland)
  • Type: Antibiotic and Antimicrobial Agents, Antiparasitic Agents, Blood System Agents, Cardiovascular Agents, Immune Function Agents, Other
  • Grade Standard: Cosmetic Grade, Feed Grade, Medicine Grade
  • Brand Name: www.foresight-care.com
  • Model Number: A-99
  • Purity: 99%, 99%
  • Manufacturer: Xi'an Wango biopharm
  • Appearance: white crystal powder
  • Assay Test Method: HPLC
  • Standard: USP/BP/CP
  • Application Area: Pharmaceutical raw intermediates
  • Stability: stable
  • Loss On Drying: 2.5%
  • Shelf life: 2 years
  • Storage: Dry place in sealed container

Packaging & Delivery

Packaging Details 1. 1g 50g 500g 1kg in a Al foil bag & 25kg/barrel.
2. The packaging can be customised.
Delivery Time 2-3days for Sample Order ; 5-15 days for Large Orders.

 

Specifications

 

1. Introduction of Lorcaserin hydrochloride (CAS NO.846589-98-8)

Lorcaserin hydrochloride is a kind of white solid. Lorcaserin hydrochloride IUPAC name is (R)-1h-3-benzazepine,8-chloro-2,3,4,5-tetrahydro-1-methyl-,hydrochloride. It belongs to APIs. Lorcaserin is the abbreviation of lorcaserin hydrochloride.


Lorcaserin is a kind of Intermediates and named "(±)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (N-1)". Lorcaserin is a weight-loss drug. It has serotonergic properties and acts as an anorectic. In October 2010, the FDA stated that it could not approve the application for lorcaserin in its present form.

2. Basic information of Lorcaserin hydrochloride (CAS NO.846589-98-8)
1) Properties of Lorcaserin hydrochloride

(1)ACD/LogP: 2.892; (2)H bond acceptors: 1; (3)H bond donors: 1; (4)Flash Point: 128.1 °C; (5)Enthalpy of Vaporization: 52.73 kJ/mol; (6)Boiling Point: 288.1 °C at 760 mmHg; (7)Vapour Pressure: 0.00238 mmHg at 25°C.


2) The following information could be converted into the structure:

(1) SMILES: Cl.Clc1cc2c(cc1)CCNC[C@@H]2C
(2) Std. InChI: InChI=1S/C11H14ClN.ClH/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9;/h2-3,6,8,13H,4-5,7H2,1H3;1H/t8-;/m0./s1
(3) Std. InChIKey: ITIHHRMYZPNGRC-QRPNPIFTSA-N

3) Mechanism of action of Lorcaserin hydrochloride

Lorcaserin is a selective 5-HT2C receptor agonist. 5-HT2C receptors are located almost exclusively in the brain, and can be found in the choroid plexus, cortex, hippocampus, cerebellum, amygdala, thalamus, and hypothalamus. The activation of 5-HT2C receptors in the hypothalamus is supposed to activate proopiomelanocortin (POMC) production and consequently promote weight loss through satiety. This hypothesis is supported by clinical trials and other studies. While it is generally thought that 5-HT2C receptors help to regulate appetite as well as mood, and endocrine secretion, the exact mechanism of appetite regulation is not yet known. Lorcaserin has shown 100x selectivity for 5-HT2C versus the closely related 5-HT2B receptor, and 17x selectivity over the 5-HT2A receptor.

4) Applications of Lorcaserin hydrochloride

Lorcaserin hydrochloride can be used to manufacture BELVIQ (lorcaserin hydrochloride). It is a serotonin 2C receptor agonist for oral administration used for chronic weight management. Lorcaserin is a selective 5-HT2C receptor agonist. BELVIQ (lorcaserin hydrochloride) is a serotonin 2C receptor agonist for oral administration used for chronic weight management. Belviq is the trade name of it.

5) Package of Lorcaserin hydrochloride

(1) Packing information of Lorcaserin hydrochloride could be seen in the following photo information. 1Kg of Lorcaserin hydrochloride is showed as follows.
(2) This chemical can also be packed according to the customer requirements and packaging specifications.

 

   

  

 

 

 

 

 

 

 

 

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Xi'An Wango Biochem Co.,Ltd  

 

 

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